List of sedating antihistamines

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Desloratadine inhibited histamine release from human mast cells in vitro.

Sedatives encompass a wide variety of drugs with different mechanisms of action that can induce depression of the central nervous system (CNS).

In the first part of the 20th century, the pharmacotherapy of anxiety and insomnia relied on barbiturates, which were replaced with benzodiazepines as drugs of choice in the second part of the previous century.

Besides those two groups of drugs, other sedatives are also used for that purpose.

Barbiturates are nonselective CNS depressants that used to be the mainstay of treatment to sedate patients or to induce and maintain sleep.